Head-To-Head Contrast: Endo International PLC (ENDP) & Alexza Pharmaceuticals (ALXA)

Endo International PLC (NASDAQ: ENDP) and Alexza Pharmaceuticals (OTCMKTS:ALXA) are both medical companies, but which is the better business? We will contrast the two companies based on the strength of their analyst recommendations, institutional ownership, earnings, dividends, risk, valuation and profitability.

Insider and Institutional Ownership

91.9% of Endo International PLC shares are owned by institutional investors. 0.5% of Endo International PLC shares are owned by company insiders. Strong institutional ownership is an indication that large money managers, endowments and hedge funds believe a stock is poised for long-term growth.


This table compares Endo International PLC and Alexza Pharmaceuticals’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Endo International PLC -126.97% 66.98% 8.38%
Alexza Pharmaceuticals -466.94% N/A -106.54%

Analyst Recommendations

This is a summary of recent recommendations and price targets for Endo International PLC and Alexza Pharmaceuticals, as provided by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Endo International PLC 1 15 4 0 2.15
Alexza Pharmaceuticals 0 0 0 0 N/A

Endo International PLC currently has a consensus price target of $11.81, suggesting a potential upside of 62.48%.

Earnings and Valuation

This table compares Endo International PLC and Alexza Pharmaceuticals’ top-line revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio NetIncome Earnings Per Share Price/Earnings Ratio
Endo International PLC $4.01 billion 0.40 -$3.35 billion ($19.28) -0.38
Alexza Pharmaceuticals N/A N/A N/A ($1.22) N/A

Alexza Pharmaceuticals has higher revenue, but lower earnings than Endo International PLC. Endo International PLC is trading at a lower price-to-earnings ratio than Alexza Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.


Endo International PLC beats Alexza Pharmaceuticals on 7 of the 8 factors compared between the two stocks.

About Endo International PLC

Endo International PLC, formerly Endo Health Solutions Inc. is a specialty healthcare solutions company focused on branded and generic pharmaceuticals, devices and services. The Company has a portfolio of branded pharmaceuticals that includes brands, such as Lidoderm, Opana ER, Voltaren Gel, Percocet, Frova, Supprelin LA, Vantas, Valstar and Fortesta Gel. The Company operates in three segments: Endo Pharmaceuticals, Qualitest and AMS. In June 2014, the Company’s subsidiary, Endo Pharmaceuticals sold its pharmaceutical drug discovery platform to AsanaBioSciences, LLC. In June 2014, Asana BioSciences, LLC, an independent member of Amneal Alliance of Companies, acquired early-stage branded pharmaceutical discovery platform of Endo Pharmaceuticals, a subsidiary of Endo International plc. In June 2014, Trendlines Group acquired intellectual property developed within the framework of an R&D agreement with the Company. In July 2014, it acquired Grupo Farmaceutico Somar.

About Alexza Pharmaceuticals

Alexza Pharmaceuticals, Inc. is a pharmaceutical company focused on the research, development and commercialization of products for the acute treatment of central nervous system conditions. The Company’s product candidates are based on the Staccato system technology. Its product candidates in development include AZ-002, which contains alprazolam as an active pharmaceutical ingredient (API) is developed for the management of patients with acute repetitive seizures, and AZ-007, which contains zaleplon as API is developed for the treatment of insomnia in patients who have difficulty falling asleep, including those patients with middle of the night awakening having difficulty falling back asleep. Its product also includes ADASUVE, which contains loxapine as API is developed for the treatment of agitation associated with schizophrenia or bipolar disorder. It has initiated a Phase IIa proof-of-concept study for AZ-002 in patients with epilepsy and has completed Phase I testing for AZ-007.

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